Distance between cities › USA › Missouri › Cascade, MO › Distance from Cascade to Mayo Book Hotels

Distance from Cascade, MO to Mayo, MD

Distance

950 mi

Time

18 hours 16 mins

Gas Cost

$89 - $172

There are 755.34 miles from Cascade to Mayo in east direction and 950 miles (1,528.88 kilometers) by car, following the I-64 route.

Cascade and Mayo are 18 hours 16 mins far apart, if you drive non-stop .

This is the fastest route from Cascade, MO to Mayo, MD.

Please note the time difference between Cascade, MO and Mayo, MD is 1 hour. The current time in Cascade is 4:11 am and the current time in Mayo is 5:11 am.

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Lowest Price Rental Cars in Cascade, MO

Planning on renting a car to go from Cascade, MO to Mayo, MD? Here there are some offers to rent a car in Cascade, MO

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Cascade »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 38.15 gallons of gas to cover the route between Cascade, MO and Mayo, MD.

The estimated cost of gas to go from Cascade to Mayo is $124.44.

During the route, an average car will release 747.43 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Cascade, MO and Mayo, MD

If you want to meet halfway between Cascade, MO and Mayo, MD or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 38.32436 and -83.077263, or 38º 19' 27.696" N, 83º 4' 38.1468" W. This location is 474.96 miles away from Cascade, MO and Mayo, MD and it would take approximately 9 hours 8 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Carter, KY, situated 478 miles from Cascade, MO and 474 miles from Mayo, MD. It would take 9 hours 36 mins to go from Cascade to Carter and 8 hours 51 mins to go from Mayo to Carter.