Distance between cities › USA › Missouri › Cascade, MO › Distance from Cascade to Simpsonville Book Hotels

Distance from Cascade, MO to Simpsonville, SC

Distance

624 mi

Time

12 hours 38 mins

Gas Cost

$58 - $113

There are 481.43 miles from Cascade to Simpsonville in southeast direction and 624 miles (1,004.23 kilometers) by car, following the I-24 route.

Cascade and Simpsonville are 12 hours 38 mins far apart, if you drive non-stop .

This is the fastest route from Cascade, MO to Simpsonville, SC.

Please note the time difference between Cascade, MO and Simpsonville, SC is 1 hour. The current time in Cascade is 6:17 am and the current time in Simpsonville is 7:17 am.

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Lowest Price Rental Cars in Cascade, MO

Planning on renting a car to go from Cascade, MO to Simpsonville, SC? Here there are some offers to rent a car in Cascade, MO

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Cascade »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 25.06 gallons of gas to cover the route between Cascade, MO and Simpsonville, SC.

The estimated cost of gas to go from Cascade to Simpsonville is $81.74.

During the route, an average car will release 490.92 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Cascade, MO and Simpsonville, SC

If you want to meet halfway between Cascade, MO and Simpsonville, SC or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 36.174377 and -86.024436, or 36º 10' 27.7572" N, 86º 1' 27.9696" W. This location is 311.96 miles away from Cascade, MO and Simpsonville, SC and it would take approximately 6 hours 19 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Brush Creek, TN, situated 314 miles from Cascade, MO and 319 miles from Simpsonville, SC. It would take 6 hours 31 mins to go from Cascade to Brush Creek and 6 hours 21 mins to go from Simpsonville to Brush Creek.

Major City Closest to Halfway Point

The major city closest to the halfway point between Cascade, MO and Simpsonville, SC is Murfreesboro, TN, situated 298 miles from Cascade, MO and 357 miles from Simpsonville, SC. It would take 6 hours 15 mins to go from Cascade to Murfreesboro and 6 hours 44 mins to go from Simpsonville to Murfreesboro.