Distance between cities › USA › Missouri › Cascade, MO › Distance from Cascade to Tupelo Book Hotels

Distance from Cascade, MO to Tupelo, MS

Distance

295 mi

Time

6 hours 7 mins

Gas Cost

$28 - $54

There are 227.76 miles from Cascade to Tupelo in southeast direction and 295 miles (474.76 kilometers) by car, following the US-78 route.

Cascade and Tupelo are 6 hours 7 mins far apart, if you drive non-stop .

This is the fastest route from Cascade, MO to Tupelo, MS.

Cascade, MO and Tupelo, MS are in the same time zone (CDT). Current time in both locations is 4:08 am.

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Lowest Price Rental Cars in Cascade, MO

Planning on renting a car to go from Cascade, MO to Tupelo, MS? Here there are some offers to rent a car in Cascade, MO

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Cascade »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 11.86 gallons of gas to cover the route between Cascade, MO and Tupelo, MS.

The estimated cost of gas to go from Cascade to Tupelo is $38.68.

During the route, an average car will release 232.31 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Cascade, MO and Tupelo, MS

If you want to meet halfway between Cascade, MO and Tupelo, MS or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 35.527925 and -90.452544, or 35º 31' 40.53" N, 90º 27' 9.1584" W. This location is 147.63 miles away from Cascade, MO and Tupelo, MS and it would take approximately 3 hours 3 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Marked Tree, AR, situated 154 miles from Cascade, MO and 143 miles from Tupelo, MS. It would take 3 hours 28 mins to go from Cascade to Marked Tree and 2 hours 43 mins to go from Tupelo to Marked Tree.