Distance between cities › USA › South Dakota › Chamberlain, SD › Distance from Chamberlain to Knox Book Hotels

Distance from Chamberlain, SD to Knox, IN

Distance

790 mi

Time

14 hours 24 mins

Gas Cost

$72 - $141

There are 668.86 miles from Chamberlain to Knox in southeast direction and 790 miles (1,271.38 kilometers) by car, following the I-90 and SD 50 route.

Chamberlain and Knox are 14 hours 24 mins far apart, if you drive non-stop .

This is the fastest route from Chamberlain, SD to Knox, IN.

Chamberlain, SD and Knox, IN are in the same time zone (CDT). Current time in both locations is 12:27 pm.

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Lowest Price Rental Cars in Chamberlain, SD

Planning on renting a car to go from Chamberlain, SD to Knox, IN? Here there are some offers to rent a car in Chamberlain, SD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Chamberlain »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 31.71 gallons of gas to cover the route between Chamberlain, SD and Knox, IN.

The estimated cost of gas to go from Chamberlain to Knox is $101.59.

During the route, an average car will release 621.20 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.20 per gallon of regular gas. Price last updated on March 11, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Chamberlain, SD and Knox, IN

If you want to meet halfway between Chamberlain, SD and Knox, IN or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 43.955202 and -92.191964, or 43º 57' 18.7272" N, 92º 11' 31.0704" W. This location is 394.75 miles away from Chamberlain, SD and Knox, IN and it would take approximately 7 hours 12 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Dover, MN, situated 379 miles from Chamberlain, SD and 413 miles from Knox, IN. It would take 6 hours 32 mins to go from Chamberlain to Dover and 7 hours 56 mins to go from Knox to Dover.

Major City Closest to Halfway Point

The major city closest to the halfway point between Chamberlain, SD and Knox, IN is Rochester, MN, situated 370 miles from Chamberlain, SD and 433 miles from Knox, IN. It would take 6 hours 24 mins to go from Chamberlain to Rochester and 8 hours 19 mins to go from Knox to Rochester.