Distance between cities › USA › Ohio › Cincinnati, OH › Distance from Cincinnati to Cairo Book Hotels

Distance from Cincinnati, OH to Cairo, IL

Distance

351 mi

Time

6 hours 35 mins

Gas Cost

$33 - $64

There are 292.19 miles from Cincinnati to Cairo in southwest direction and 351 miles (564.88 kilometers) by car, following the Western Kentucky Parkway route.

Cincinnati and Cairo are 6 hours 35 mins far apart, if you drive non-stop .

This is the fastest route from Cincinnati, OH to Cairo, IL. The halfway point is Spurgeon, IN.

Please note the time difference between Cincinnati, OH and Cairo, IL is 1 hour. The current time in Cincinnati is 6:58 am and the current time in Cairo is 5:58 am.

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Lowest Price Rental Cars in Cincinnati, OH

Planning on renting a car to go from Cincinnati, OH to Cairo, IL? Here there are some offers to rent a car in Cincinnati, OH

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Cincinnati »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 14.08 gallons of gas to cover the route between Cincinnati, OH and Cairo, IL.

The estimated cost of gas to go from Cincinnati to Cairo is $45.92.

During the route, an average car will release 275.82 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Cincinnati, OH and Cairo, IL

If you want to meet halfway between Cincinnati, OH and Cairo, IL or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 38.201889 and -87.210938, or 38º 12' 6.8004" N, 87º 12' 39.3768" W. This location is 175.28 miles away from Cincinnati, OH and Cairo, IL and it would take approximately 3 hours 17 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Spurgeon, IN, situated 194 miles from Cincinnati, OH and 192 miles from Cairo, IL. It would take 3 hours 2 mins to go from Cincinnati to Spurgeon and 3 hours 2 mins to go from Cairo to Spurgeon.

Major City Closest to Halfway Point

The major city closest to the halfway point between Cincinnati, OH and Cairo, IL is Evansville, IN, situated 218 miles from Cincinnati, OH and 165 miles from Cairo, IL. It would take 3 hours 22 mins to go from Cincinnati to and 2 hours 49 mins to go from Cairo to Evansville.