Distance between cities › USA › Florida › Cottondale, FL › Distance from Cottondale to Florence Book Hotels

Distance from Cottondale, FL to Florence, MO

Distance

820 mi

Time

16 hours 32 mins

Gas Cost

$76 - $149

There are 689.62 miles from Cottondale to Florence in northwest direction and 820 miles (1,319.66 kilometers) by car, following the I-22 route.

Cottondale and Florence are 16 hours 32 mins far apart, if you drive non-stop .

This is the fastest route from Cottondale, FL to Florence, MO.

Cottondale, FL and Florence, MO are in the same time zone (CDT). Current time in both locations is 7:03 pm.

Any questions or tips to share?

Share with fellow travellers any question or tips about the route from Cottondale, FL to Florence, MO:

Lowest Price Rental Cars in Cottondale, FL

Planning on renting a car to go from Cottondale, FL to Florence, MO? Here there are some offers to rent a car in Cottondale, FL

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Cottondale »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 32.95 gallons of gas to cover the route between Cottondale, FL and Florence, MO.

The estimated cost of gas to go from Cottondale to Florence is $107.48.

During the route, an average car will release 645.53 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Cottondale, FL and Florence, MO

If you want to meet halfway between Cottondale, FL and Florence, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 34.746075 and -89.451989, or 34º 44' 45.87" N, 89º 27' 7.1604" W. This location is 410.21 miles away from Cottondale, FL and Florence, MO and it would take approximately 8 hours 16 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Holly Springs, MS, situated 415 miles from Cottondale, FL and 408 miles from Florence, MO. It would take 7 hours 56 mins to go from Cottondale to Holly Springs and 8 hours 40 mins to go from Florence to Holly Springs.