Distance between cities › USA › Missouri › Guilford, MO › Distance from Guilford to Lyons Book Hotels

Distance from Guilford, MO to Lyons, CO

Distance

636 mi

Time

11 hours 51 mins

Gas Cost

$59 - $115

There are 555.67 miles from Guilford to Lyons in west direction and 636 miles (1,023.54 kilometers) by car, following the I-80 route.

Guilford and Lyons are 11 hours 51 mins far apart, if you drive non-stop .

This is the fastest route from Guilford, MO to Lyons, CO.

Please note the time difference between Guilford, MO and Lyons, CO is 1 hour. The current time in Guilford is 9:56 pm and the current time in Lyons is 8:56 pm.

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Lowest Price Rental Cars in Guilford, MO

Planning on renting a car to go from Guilford, MO to Lyons, CO? Here there are some offers to rent a car in Guilford, MO

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Guilford »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 25.54 gallons of gas to cover the route between Guilford, MO and Lyons, CO.

The estimated cost of gas to go from Guilford to Lyons is $83.32.

During the route, an average car will release 500.44 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Guilford, MO and Lyons, CO

If you want to meet halfway between Guilford, MO and Lyons, CO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 40.830775 and -99.952543, or 40º 49' 50.79" N, 99º 57' 9.1548" W. This location is 318.01 miles away from Guilford, MO and Lyons, CO and it would take approximately 5 hours 55 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Cozad, NE, situated 320 miles from Guilford, MO and 317 miles from Lyons, CO. It would take 6 hours 13 mins to go from Guilford to Cozad and 5 hours 42 mins to go from Lyons to Cozad.