Distance between cities › USA › South Dakota › Iona, SD › Distance from Iona to Murphysboro Book Hotels

Distance from Iona, SD to Murphysboro, IL

Distance

819 mi

Time

16 hours 1 min

Gas Cost

$76 - $148

There are 663.27 miles from Iona to Murphysboro in southeast direction and 819 miles (1,318.05 kilometers) by car, following the I-29 and I-80 Local and US-6 route.

Iona and Murphysboro are 16 hours 1 min far apart, if you drive non-stop .

This is the fastest route from Iona, SD to Murphysboro, IL.

Iona, SD and Murphysboro, IL are in the same time zone (CDT). Current time in both locations is 2:22 pm.

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Lowest Price Rental Cars in Iona, SD

Planning on renting a car to go from Iona, SD to Murphysboro, IL? Here there are some offers to rent a car in Iona, SD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Iona »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 32.88 gallons of gas to cover the route between Iona, SD and Murphysboro, IL.

The estimated cost of gas to go from Iona to Murphysboro is $107.26.

During the route, an average car will release 644.24 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Iona, SD and Murphysboro, IL

If you want to meet halfway between Iona, SD and Murphysboro, IL or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 39.948025 and -94.946804, or 39º 56' 52.89" N, 94º 56' 48.4944" W. This location is 409.39 miles away from Iona, SD and Murphysboro, IL and it would take approximately 8 hours to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Amazonia, MO, situated 420 miles from Iona, SD and 399 miles from Murphysboro, IL. It would take 8 hours 26 mins to go from Iona to Amazonia and 7 hours 40 mins to go from Murphysboro to Amazonia.