Distance between cities › USA › Mississippi › Isola, MS › Distance from Isola to Argyle Book Hotels

Distance from Isola, MS to Argyle, MO

Distance

451 mi

Time

9 hours 46 mins

Gas Cost

$42 - $82

There are 356.83 miles from Isola to Argyle in northwest direction and 451 miles (725.81 kilometers) by car, following the US-63 route.

Isola and Argyle are 9 hours 46 mins far apart, if you drive non-stop .

This is the fastest route from Isola, MS to Argyle, MO. The halfway point is Kewanee, MO.

Isola, MS and Argyle, MO are in the same time zone (CDT). Current time in both locations is 11:05 am.

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Lowest Price Rental Cars in Isola, MS

Planning on renting a car to go from Isola, MS to Argyle, MO? Here there are some offers to rent a car in Isola, MS

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Isola »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 18.13 gallons of gas to cover the route between Isola, MS and Argyle, MO.

The estimated cost of gas to go from Isola to Argyle is $59.13.

During the route, an average car will release 355.12 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Isola, MS and Argyle, MO

If you want to meet halfway between Isola, MS and Argyle, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 36.674355 and -89.539551, or 36º 40' 27.678" N, 89º 32' 22.3836" W. This location is 225.67 miles away from Isola, MS and Argyle, MO and it would take approximately 4 hours 53 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Kewanee, MO, situated 280 miles from Isola, MS and 267 miles from Argyle, MO. It would take 4 hours 45 mins to go from Isola to Kewanee and 4 hours 20 mins to go from Argyle to Kewanee.