Distance between cities › USA › Mississippi › Isola, MS › Distance from Isola to Old Appleton Book Hotels

Distance from Isola, MS to Old Appleton, MO

Distance

338 mi

Time

6 hours 45 mins

Gas Cost

$31 - $60

There are 303.59 miles from Isola to Old Appleton in north direction and 338 miles (543.96 kilometers) by car, following the I-55 and US-78 route.

Isola and Old Appleton are 6 hours 45 mins far apart, if you drive non-stop .

This is the fastest route from Isola, MS to Old Appleton, MO.

Isola, MS and Old Appleton, MO are in the same time zone (CDT). Current time in both locations is 5:02 pm.

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Lowest Price Rental Cars in Isola, MS

Planning on renting a car to go from Isola, MS to Old Appleton, MO? Here there are some offers to rent a car in Isola, MS

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Isola »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 13.59 gallons of gas to cover the route between Isola, MS and Old Appleton, MO.

The estimated cost of gas to go from Isola to Old Appleton is $43.55.

During the route, an average car will release 266.30 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.20 per gallon of regular gas. Price last updated on March 11, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Isola, MS and Old Appleton, MO

If you want to meet halfway between Isola, MS and Old Appleton, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 35.362776 and -90.279628, or 35º 21' 45.9936" N, 90º 16' 46.6608" W. This location is 169.22 miles away from Isola, MS and Old Appleton, MO and it would take approximately 3 hours 22 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Turrell, AR, situated 172 miles from Isola, MS and 169 miles from Old Appleton, MO. It would take 3 hours 46 mins to go from Isola to Turrell and 3 hours 5 mins to go from Old Appleton to Turrell.

Major City Closest to Halfway Point

The major city closest to the halfway point between Isola, MS and Old Appleton, MO is Memphis, TN, situated 148 miles from Isola, MS and 193 miles from Old Appleton, MO. It would take 3 hours 19 mins to go from Isola to Memphis and 3 hours 30 mins to go from Old Appleton to Memphis.