Distance between cities › USA › Illinois › Itasca, IL › Distance from Itasca to Mayesville Book Hotels

Distance from Itasca, IL to Mayesville, SC

Distance

856 mi

Time

16 hours 49 mins

Gas Cost

$80 - $155

There are 695.73 miles from Itasca to Mayesville in southeast direction and 856 miles (1,377.60 kilometers) by car, following the I-65 route.

Itasca and Mayesville are 16 hours 49 mins far apart, if you drive non-stop .

This is the fastest route from Itasca, IL to Mayesville, SC.

Please note the time difference between Itasca, IL and Mayesville, SC is 1 hour. The current time in Itasca is 9:06 am and the current time in Mayesville is 10:06 am.

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Lowest Price Rental Cars in Itasca, IL

Planning on renting a car to go from Itasca, IL to Mayesville, SC? Here there are some offers to rent a car in Itasca, IL

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Itasca »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 34.37 gallons of gas to cover the route between Itasca, IL and Mayesville, SC.

The estimated cost of gas to go from Itasca to Mayesville is $112.11.

During the route, an average car will release 673.33 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Itasca, IL and Mayesville, SC

If you want to meet halfway between Itasca, IL and Mayesville, SC or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 37.588765 and -84.313608, or 37º 35' 19.554" N, 84º 18' 48.9888" W. This location is 427.87 miles away from Itasca, IL and Mayesville, SC and it would take approximately 8 hours 24 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Berea, KY, situated 429 miles from Itasca, IL and 429 miles from Mayesville, SC. It would take 8 hours 11 mins to go from Itasca to Berea and 8 hours 41 mins to go from Mayesville to Berea.