Distance between cities › USA › South Dakota › Madison, SD › Distance from Madison to Adrian Book Hotels

Distance from Madison, SD to Adrian, MO

Distance

464 mi

Time

8 hours 26 mins

Gas Cost

$42 - $83

There are 413.20 miles from Madison to Adrian in southeast direction and 464 miles (746.74 kilometers) by car, following the I-29 route.

Madison and Adrian are 8 hours 26 mins far apart, if you drive non-stop .

This is the fastest route from Madison, SD to Adrian, MO.

Madison, SD and Adrian, MO are in the same time zone (CDT). Current time in both locations is 9:54 pm.

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Lowest Price Rental Cars in Madison, SD

Planning on renting a car to go from Madison, SD to Adrian, MO? Here there are some offers to rent a car in Madison, SD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Madison »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 18.61 gallons of gas to cover the route between Madison, SD and Adrian, MO.

The estimated cost of gas to go from Madison to Adrian is $59.64.

During the route, an average car will release 364.70 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.20 per gallon of regular gas. Price last updated on March 11, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Madison, SD and Adrian, MO

If you want to meet halfway between Madison, SD and Adrian, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 41.232033 and -95.858085, or 41º 13' 55.3188" N, 95º 51' 29.106" W. This location is 231.75 miles away from Madison, SD and Adrian, MO and it would take approximately 4 hours 13 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Manawa, IA, situated 232 miles from Madison, SD and 235 miles from Adrian, MO. It would take 4 hours 19 mins to go from Madison to Manawa and 4 hours 29 mins to go from Adrian to Manawa.

Major City Closest to Halfway Point

The major city closest to the halfway point between Madison, SD and Adrian, MO is Omaha, NE, situated 232 miles from Madison, SD and 240 miles from Adrian, MO. It would take 4 hours 12 mins to go from Madison to Omaha and 4 hours 32 mins to go from Adrian to Omaha.