There are 432.63 miles from Madison to Appleton City in southeast direction and 494 miles (795.02 kilometers) by car, following the I-29 route.
Madison and Appleton City are 9 hours 2 mins far apart, if you drive non-stop .
This is the fastest route from Madison, SD to Appleton City, MO. The halfway point is Pacific Junction, IA.
Madison, SD and Appleton City, MO are in the same time zone (CDT). Current time in both locations is 9:55 pm.
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