Distance between cities › USA › South Dakota › Madison, SD › Distance from Madison to Brookline Book Hotels

Distance from Madison, SD to Brookline, MO

Distance

580 mi

Time

10 hours 44 mins

Gas Cost

$54 - $105

There are 509.95 miles from Madison to Brookline in southeast direction and 580 miles (933.42 kilometers) by car, following the I-29 route.

Madison and Brookline are 10 hours 44 mins far apart, if you drive non-stop .

This is the fastest route from Madison, SD to Brookline, MO.

Madison, SD and Brookline, MO are in the same time zone (CDT). Current time in both locations is 3:53 am.

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Lowest Price Rental Cars in Madison, SD

Planning on renting a car to go from Madison, SD to Brookline, MO? Here there are some offers to rent a car in Madison, SD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Madison »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 23.30 gallons of gas to cover the route between Madison, SD and Brookline, MO.

The estimated cost of gas to go from Madison to Brookline is $76.

During the route, an average car will release 456.48 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Madison, SD and Brookline, MO

If you want to meet halfway between Madison, SD and Brookline, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 40.428822 and -95.56708, or 40º 25' 43.7592" N, 95º 34' 1.488" W. This location is 290.07 miles away from Madison, SD and Brookline, MO and it would take approximately 5 hours 22 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Rock Port, MO, situated 297 miles from Madison, SD and 287 miles from Brookline, MO. It would take 5 hours 20 mins to go from Madison to Rock Port and 5 hours 33 mins to go from Brookline to Rock Port.