Distance between cities › USA › South Dakota › Madison, SD › Distance from Madison to Palmyra Book Hotels

Distance from Madison, SD to Palmyra, MO

Distance

546 mi

Time

10 hours 3 mins

Gas Cost

$51 - $99

There are 408.90 miles from Madison to Palmyra in southeast direction and 546 miles (878.70 kilometers) by car, following the I-29 route.

Madison and Palmyra are 10 hours 3 mins far apart, if you drive non-stop .

This is the fastest route from Madison, SD to Palmyra, MO.

Madison, SD and Palmyra, MO are in the same time zone (CDT). Current time in both locations is 5:13 am.

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Lowest Price Rental Cars in Madison, SD

Planning on renting a car to go from Madison, SD to Palmyra, MO? Here there are some offers to rent a car in Madison, SD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Madison »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 21.94 gallons of gas to cover the route between Madison, SD and Palmyra, MO.

The estimated cost of gas to go from Madison to Palmyra is $71.56.

During the route, an average car will release 429.78 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Madison, SD and Palmyra, MO

If you want to meet halfway between Madison, SD and Palmyra, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 40.431395 and -95.568261, or 40º 25' 53.022" N, 95º 34' 5.7396" W. This location is 273.11 miles away from Madison, SD and Palmyra, MO and it would take approximately 5 hours 1 min to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Rock Port, MO, situated 297 miles from Madison, SD and 253 miles from Palmyra, MO. It would take 5 hours 20 mins to go from Madison to Rock Port and 4 hours 52 mins to go from Palmyra to Rock Port.