There are 308.24 miles from Madison to Powersville in southeast direction and 421 miles (677.53 kilometers) by car, following the I-29 route.
Madison and Powersville are 8 hours 2 mins far apart, if you drive non-stop .
This is the fastest route from Madison, SD to Powersville, MO.
Madison, SD and Powersville, MO are in the same time zone (CDT). Current time in both locations is 3:38 am.
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