There are 259.42 miles from McCook to Lancaster in southwest direction and 335 miles (539.13 kilometers) by car, following the I-80 route.
McCook and Lancaster are 6 hours 31 mins far apart, if you drive non-stop .
This is the fastest route from McCook, IL to Lancaster, MO. The halfway point is Maysville, IA.
McCook, IL and Lancaster, MO are in the same time zone (CDT). Current time in both locations is 11:39 am.
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