There are 342.33 miles from McCook to Syracuse in southwest direction and 430 miles (692.02 kilometers) by car, following the I-55 route.
McCook and Syracuse are 8 hours 14 mins far apart, if you drive non-stop .
This is the fastest route from McCook, IL to Syracuse, MO. The halfway point is Alexander, IL.
McCook, IL and Syracuse, MO are in the same time zone (CDT). Current time in both locations is 3:45 pm.
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