Distance between cities › USA › Arizona › Mesa, AZ › Distance from Mesa to Florence Book Hotels

Distance from Mesa, AZ to Florence, MO

Distance

1,282 mi

Time

23 hours 53 mins

Gas Cost

$119 - $232

There are 1,110.29 miles from Mesa to Florence in northeast direction and 1,282 miles (2,063.18 kilometers) by car, following the I-40 and AZ 77 route.

Mesa and Florence are 23 hours 53 mins far apart, if you drive non-stop .

This is the fastest route from Mesa, AZ to Florence, MO. The halfway point is Bushland, TX.

Please note the time difference between Mesa, AZ and Florence, MO is 2 hours. The current time in Mesa is 5:15 am and the current time in Florence is 7:15 am.

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Lowest Price Rental Cars in Mesa, AZ

Planning on renting a car to go from Mesa, AZ to Florence, MO? Here there are some offers to rent a car in Mesa, AZ

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Mesa »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 51.48 gallons of gas to cover the route between Mesa, AZ and Florence, MO.

The estimated cost of gas to go from Mesa to Florence is $167.93.

During the route, an average car will release 1,008.62 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Mesa, AZ and Florence, MO

If you want to meet halfway between Mesa, AZ and Florence, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 35.191746 and -102.073067, or 35º 11' 30.2856" N, 102º 4' 23.0412" W. This location is 640.94 miles away from Mesa, AZ and Florence, MO and it would take approximately 11 hours 56 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Bushland, TX, situated 676 miles from Mesa, AZ and 669 miles from Florence, MO. It would take 9 hours 59 mins to go from Mesa to Bushland and 10 hours 6 mins to go from Florence to Bushland.

Major City Closest to Halfway Point

The major city closest to the halfway point between Mesa, AZ and Florence, MO is Amarillo, TX, situated 692 miles from Mesa, AZ and 657 miles from Florence, MO. It would take 10 hours 15 mins to go from Mesa to and 9 hours 57 mins to go from Florence to Amarillo.