Distance between cities › USA › Ohio › Mesopotamia, OH › Distance from Mesopotamia to Pendleton Book Hotels

Distance from Mesopotamia, OH to Pendleton, IN

Distance

326 mi

Time

6 hours 29 mins

Gas Cost

$30 - $58

There are 270.06 miles from Mesopotamia to Pendleton in southwest direction and 326 miles (524.65 kilometers) by car, following the I-71 route.

Mesopotamia and Pendleton are 6 hours 29 mins far apart, if you drive non-stop .

This is the fastest route from Mesopotamia, OH to Pendleton, IN.

Mesopotamia, OH and Pendleton, IN are in the same time zone (EDT). Current time in both locations is 9:36 pm.

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Lowest Price Rental Cars in Mesopotamia, OH

Planning on renting a car to go from Mesopotamia, OH to Pendleton, IN? Here there are some offers to rent a car in Mesopotamia, OH

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Mesopotamia »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 13.11 gallons of gas to cover the route between Mesopotamia, OH and Pendleton, IN.

The estimated cost of gas to go from Mesopotamia to Pendleton is $41.99.

During the route, an average car will release 256.77 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.20 per gallon of regular gas. Price last updated on March 11, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Mesopotamia, OH and Pendleton, IN

If you want to meet halfway between Mesopotamia, OH and Pendleton, IN or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 40.823966 and -83.401667, or 40º 49' 26.2776" N, 83º 24' 6.0012" W. This location is 163.17 miles away from Mesopotamia, OH and Pendleton, IN and it would take approximately 3 hours 14 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Kirby, OH, situated 165 miles from Mesopotamia, OH and 164 miles from Pendleton, IN. It would take 3 hours 20 mins to go from Mesopotamia to Kirby and 3 hours 15 mins to go from Pendleton to Kirby.