Distance between cities › USA › Virginia › Penhook, VA › Distance from Penhook to Mayesville Book Hotels

Distance from Penhook, VA to Mayesville, SC

Distance

255 mi

Time

5 hours 18 mins

Gas Cost

$23 - $45

There are 209.47 miles from Penhook to Mayesville in south direction and 255 miles (410.38 kilometers) by car, following the I-73 and I-74 and US-220 route.

Penhook and Mayesville are 5 hours 18 mins far apart, if you drive non-stop .

This is the fastest route from Penhook, VA to Mayesville, SC.

Penhook, VA and Mayesville, SC are in the same time zone (EDT). Current time in both locations is 10:43 pm.

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Lowest Price Rental Cars in Penhook, VA

Planning on renting a car to go from Penhook, VA to Mayesville, SC? Here there are some offers to rent a car in Penhook, VA

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Penhook »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 10.24 gallons of gas to cover the route between Penhook, VA and Mayesville, SC.

The estimated cost of gas to go from Penhook to Mayesville is $32.81.

During the route, an average car will release 200.64 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.20 per gallon of regular gas. Price last updated on March 11, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Penhook, VA and Mayesville, SC

If you want to meet halfway between Penhook, VA and Mayesville, SC or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 35.562861 and -79.804335, or 35º 33' 46.2996" N, 79º 48' 15.606" W. This location is 127.50 miles away from Penhook, VA and Mayesville, SC and it would take approximately 2 hours 39 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Seagrove, NC, situated 129 miles from Penhook, VA and 128 miles from Mayesville, SC. It would take 2 hours 36 mins to go from Penhook to Seagrove and 2 hours 47 mins to go from Mayesville to Seagrove.

Major City Closest to Halfway Point

The major city closest to the halfway point between Penhook, VA and Mayesville, SC is High Point, NC, situated 86 miles from Penhook, VA and 162 miles from Mayesville, SC. It would take 2 hours 8 mins to go from Penhook to High Point and 3 hours 27 mins to go from Mayesville to High Point.