Distance between cities › USA › Virginia › Penhook, VA › Distance from Penhook to Tupelo Book Hotels

Distance from Penhook, VA to Tupelo, MS

Distance

646 mi

Time

12 hours 29 mins

Gas Cost

$59 - $115

There are 543.09 miles from Penhook to Tupelo in southwest direction and 646 miles (1,039.64 kilometers) by car, following the I-81 and US-52 route.

Penhook and Tupelo are 12 hours 29 mins far apart, if you drive non-stop .

This is the fastest route from Penhook, VA to Tupelo, MS.

Please note the time difference between Penhook, VA and Tupelo, MS is 1 hour. The current time in Penhook is 12:40 am (Mar 12) and the current time in Tupelo is 11:40 pm (Mar 11).

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Lowest Price Rental Cars in Penhook, VA

Planning on renting a car to go from Penhook, VA to Tupelo, MS? Here there are some offers to rent a car in Penhook, VA

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Penhook »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 25.93 gallons of gas to cover the route between Penhook, VA and Tupelo, MS.

The estimated cost of gas to go from Penhook to Tupelo is $83.08.

During the route, an average car will release 508.03 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.20 per gallon of regular gas. Price last updated on March 11, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Penhook, VA and Tupelo, MS

If you want to meet halfway between Penhook, VA and Tupelo, MS or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 35.873914 and -84.246541, or 35º 52' 26.0904" N, 84º 14' 47.5476" W. This location is 322.84 miles away from Penhook, VA and Tupelo, MS and it would take approximately 6 hours 14 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Farragut, TN, situated 315 miles from Penhook, VA and 335 miles from Tupelo, MS. It would take 6 hours 2 mins to go from Penhook to Farragut and 6 hours 38 mins to go from Tupelo to Farragut.

Major City Closest to Halfway Point

The major city closest to the halfway point between Penhook, VA and Tupelo, MS is Knoxville, TN, situated 299 miles from Penhook, VA and 348 miles from Tupelo, MS. It would take 5 hours 42 mins to go from Penhook to Knoxville and 6 hours 51 mins to go from Tupelo to Knoxville.