Distance between cities › USA › Maryland › Poolesville, MD › Distance from Poolesville to Buffalo Book Hotels

Distance from Poolesville, MD to Buffalo, SC

Distance

493 mi

Time

9 hours 55 mins

Gas Cost

$46 - $89

There are 385.63 miles from Poolesville to Buffalo in southwest direction and 493 miles (793.41 kilometers) by car, following the I-81 route.

Poolesville and Buffalo are 9 hours 55 mins far apart, if you drive non-stop .

This is the fastest route from Poolesville, MD to Buffalo, SC. The halfway point is Ironto, VA.

Poolesville, MD and Buffalo, SC are in the same time zone (EDT). Current time in both locations is 7:35 pm.

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Lowest Price Rental Cars in Poolesville, MD

Planning on renting a car to go from Poolesville, MD to Buffalo, SC? Here there are some offers to rent a car in Poolesville, MD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Poolesville »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 19.80 gallons of gas to cover the route between Poolesville, MD and Buffalo, SC.

The estimated cost of gas to go from Poolesville to Buffalo is $64.58.

During the route, an average car will release 387.88 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Poolesville, MD and Buffalo, SC

If you want to meet halfway between Poolesville, MD and Buffalo, SC or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 37.196995 and -80.283043, or 37º 11' 49.182" N, 80º 16' 58.9548" W. This location is 246.48 miles away from Poolesville, MD and Buffalo, SC and it would take approximately 4 hours 57 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Ironto, VA, situated 236 miles from Poolesville, MD and 258 miles from Buffalo, SC. It would take 4 hours 2 mins to go from Poolesville to Ironto and 4 hours 23 mins to go from Buffalo to Ironto.