Distance between cities › USA › Maryland › Poolesville, MD › Distance from Poolesville to Mayesville Book Hotels

Distance from Poolesville, MD to Mayesville, SC

Distance

457 mi

Time

8 hours 50 mins

Gas Cost

$43 - $83

There are 388.54 miles from Poolesville to Mayesville in southwest direction and 457 miles (735.47 kilometers) by car, following the I-95 route.

Poolesville and Mayesville are 8 hours 50 mins far apart, if you drive non-stop .

This is the fastest route from Poolesville, MD to Mayesville, SC.

Poolesville, MD and Mayesville, SC are in the same time zone (EDT). Current time in both locations is 4:25 pm.

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Lowest Price Rental Cars in Poolesville, MD

Planning on renting a car to go from Poolesville, MD to Mayesville, SC? Here there are some offers to rent a car in Poolesville, MD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Poolesville »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 18.35 gallons of gas to cover the route between Poolesville, MD and Mayesville, SC.

The estimated cost of gas to go from Poolesville to Mayesville is $59.86.

During the route, an average car will release 359.52 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Poolesville, MD and Mayesville, SC

If you want to meet halfway between Poolesville, MD and Mayesville, SC or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 36.26411 and -77.723927, or 36º 15' 50.796" N, 77º 43' 26.1372" W. This location is 228.46 miles away from Poolesville, MD and Mayesville, SC and it would take approximately 4 hours 25 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Enfield, NC, situated 245 miles from Poolesville, MD and 224 miles from Mayesville, SC. It would take 4 hours 47 mins to go from Poolesville to Enfield and 4 hours 20 mins to go from Mayesville to Enfield.