Distance between cities › USA › Missouri › Saint James, MO › Distance from Saint James to Lyons Book Hotels

Distance from Saint James, MO to Lyons, IN

Distance

283 mi

Time

5 hours 47 mins

Gas Cost

$26 - $51

There are 254.46 miles from Saint James to Lyons in northeast direction and 283 miles (455.44 kilometers) by car, following the US-50 route.

Saint James and Lyons are 5 hours 47 mins far apart, if you drive non-stop .

This is the fastest route from Saint James, MO to Lyons, IN.

Please note the time difference between Saint James, MO and Lyons, IN is 1 hour. The current time in Saint James is 7:06 pm and the current time in Lyons is 8:06 pm.

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Lowest Price Rental Cars in Saint James, MO

Planning on renting a car to go from Saint James, MO to Lyons, IN? Here there are some offers to rent a car in Saint James, MO

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Saint James »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 11.38 gallons of gas to cover the route between Saint James, MO and Lyons, IN.

The estimated cost of gas to go from Saint James to Lyons is $37.12.

During the route, an average car will release 222.93 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Saint James, MO and Lyons, IN

If you want to meet halfway between Saint James, MO and Lyons, IN or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 38.624017 and -89.396738, or 38º 37' 26.4612" N, 89º 23' 48.2568" W. This location is 141.66 miles away from Saint James, MO and Lyons, IN and it would take approximately 2 hours 53 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Carlyle, IL, situated 145 miles from Saint James, MO and 138 miles from Lyons, IN. It would take 2 hours 47 mins to go from Saint James to Carlyle and 2 hours 59 mins to go from Lyons to Carlyle.