Distance between cities › USA › Texas › Santo, TX › Distance from Santo to Panhandle Book Hotels

Distance from Santo, TX to Panhandle, TX

Distance

324 mi

Time

6 hours 4 mins

Gas Cost

$30 - $58

There are 262.23 miles from Santo to Panhandle in northwest direction and 324 miles (521.43 kilometers) by car, following the US-281 route.

Santo and Panhandle are 6 hours 4 mins far apart, if you drive non-stop .

This is the fastest route from Santo, TX to Panhandle, TX. The halfway point is Vernon, TX.

Santo, TX and Panhandle, TX are in the same time zone (CDT). Current time in both locations is 12:57 am.

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Lowest Price Rental Cars in Santo, TX

Planning on renting a car to go from Santo, TX to Panhandle, TX? Here there are some offers to rent a car in Santo, TX

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Santo »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 13.02 gallons of gas to cover the route between Santo, TX and Panhandle, TX.

The estimated cost of gas to go from Santo to Panhandle is $41.74.

During the route, an average car will release 255.07 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.21 per gallon of regular gas. Price last updated on March 11, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Santo, TX and Panhandle, TX

If you want to meet halfway between Santo, TX and Panhandle, TX or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 34.186470 and -99.355873, or 34º 11' 11.292" N, 99º 21' 21.1428" W. This location is 162.09 miles away from Santo, TX and Panhandle, TX and it would take approximately 3 hours 2 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Vernon, TX, situated 159 miles from Santo, TX and 164 miles from Panhandle, TX. It would take 3 hours 14 mins to go from Santo to Vernon and 3 hours 3 mins to go from Panhandle to Vernon.