Distance between cities › USA › South Dakota › Vermillion, SD › Distance from Vermillion to Cairo Book Hotels

Distance from Vermillion, SD to Cairo, OH

Distance

775 mi

Time

14 hours 46 mins

Gas Cost

$72 - $140

There are 674.29 miles from Vermillion to Cairo in east direction and 775 miles (1,247.24 kilometers) by car, following the I-80 route.

Vermillion and Cairo are 14 hours 46 mins far apart, if you drive non-stop .

This is the fastest route from Vermillion, SD to Cairo, OH. The halfway point is Davenport, IA.

Please note the time difference between Vermillion, SD and Cairo, OH is 1 hour. The current time in Vermillion is 2:03 pm and the current time in Cairo is 3:03 pm.

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Lowest Price Rental Cars in Vermillion, SD

Planning on renting a car to go from Vermillion, SD to Cairo, OH? Here there are some offers to rent a car in Vermillion, SD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Vermillion »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 31.12 gallons of gas to cover the route between Vermillion, SD and Cairo, OH.

The estimated cost of gas to go from Vermillion to Cairo is $101.50.

During the route, an average car will release 609.61 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Vermillion, SD and Cairo, OH

If you want to meet halfway between Vermillion, SD and Cairo, OH or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 41.569729 and -90.660095, or 41º 34' 11.0244" N, 90º 39' 36.342" W. This location is 387.39 miles away from Vermillion, SD and Cairo, OH and it would take approximately 7 hours 23 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest and also the major city is Davenport, IA, situated 383.21 miles from Vermillion, SD and 372.61 miles from Cairo, OH. It would take 5 hours 59 mins to go from Vermillion to Davenport and 6 hours 29 mins to go from Cairo to Davenport.