Distance between cities › USA › Illinois › Wayne, IL › Distance from Wayne to Murphysboro Book Hotels

Distance from Wayne, IL to Murphysboro, IL

Distance

362 mi

Time

6 hours 56 mins

Gas Cost

$38 - $73

There are 294.99 miles from Wayne to Murphysboro in south direction and 362 miles (582.58 kilometers) by car, following the I-57 route.

Wayne and Murphysboro are 6 hours 56 mins far apart, if you drive non-stop .

This is the fastest route from Wayne, IL to Murphysboro, IL.

Wayne, IL and Murphysboro, IL are in the same time zone (CDT). Current time in both locations is 4:05 pm.

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Lowest Price Rental Cars in Wayne, IL

Planning on renting a car to go from Wayne, IL to Murphysboro, IL? Here there are some offers to rent a car in Wayne, IL

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Wayne »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 14.54 gallons of gas to cover the route between Wayne, IL and Murphysboro, IL.

The estimated cost of gas to go from Wayne to Murphysboro is $53.

During the route, an average car will release 284.81 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.65 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Wayne, IL and Murphysboro, IL

If you want to meet halfway between Wayne, IL and Murphysboro, IL or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 39.858665 and -88.265042, or 39º 51' 31.194" N, 88º 15' 54.1512" W. This location is 180.98 miles away from Wayne, IL and Murphysboro, IL and it would take approximately 3 hours 28 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Pesotum, IL, situated 178 miles from Wayne, IL and 186 miles from Murphysboro, IL. It would take 3 hours 28 mins to go from Wayne to Pesotum and 3 hours 31 mins to go from Murphysboro to Pesotum.