Distance between cities › USA › Illinois › Wayne, IL › Distance from Wayne to Syracuse Book Hotels

Distance from Wayne, IL to Syracuse, OH

Distance

485 mi

Time

9 hours 35 mins

Gas Cost

$45 - $88

There are 387.37 miles from Wayne to Syracuse in southeast direction and 485 miles (780.53 kilometers) by car, following the I-65 route.

Wayne and Syracuse are 9 hours 35 mins far apart, if you drive non-stop .

This is the fastest route from Wayne, IL to Syracuse, OH.

Please note the time difference between Wayne, IL and Syracuse, OH is 1 hour. The current time in Wayne is 8:31 pm and the current time in Syracuse is 9:31 pm.

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Lowest Price Rental Cars in Wayne, IL

Planning on renting a car to go from Wayne, IL to Syracuse, OH? Here there are some offers to rent a car in Wayne, IL

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Wayne »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 19.47 gallons of gas to cover the route between Wayne, IL and Syracuse, OH.

The estimated cost of gas to go from Wayne to Syracuse is $63.52.

During the route, an average car will release 381.51 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Wayne, IL and Syracuse, OH

If you want to meet halfway between Wayne, IL and Syracuse, OH or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 39.85278 and -85.482001, or 39º 51' 10.008" N, 85º 28' 55.2036" W. This location is 242.43 miles away from Wayne, IL and Syracuse, OH and it would take approximately 4 hours 47 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Greensboro, IN, situated 253 miles from Wayne, IL and 238 miles from Syracuse, OH. It would take 5 hours 12 mins to go from Wayne to Greensboro and 4 hours 51 mins to go from Syracuse to Greensboro.