Distance between cities › USA › Virginia › Appalachia, VA › Distance from Appalachia to Cairo Book Hotels

Distance from Appalachia, VA to Cairo, MO

Distance

665 mi

Time

12 hours 55 mins

Gas Cost

$62 - $121

There are 554.06 miles from Appalachia to Cairo in northwest direction and 665 miles (1,070.21 kilometers) by car, following the I-64 and SR 62 route.

Appalachia and Cairo are 12 hours 55 mins far apart, if you drive non-stop .

This is the fastest route from Appalachia, VA to Cairo, MO.

Please note the time difference between Appalachia, VA and Cairo, MO is 1 hour. The current time in Appalachia is 9:47 pm and the current time in Cairo is 8:47 pm.

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Lowest Price Rental Cars in Appalachia, VA

Planning on renting a car to go from Appalachia, VA to Cairo, MO? Here there are some offers to rent a car in Appalachia, VA

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Appalachia »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 26.71 gallons of gas to cover the route between Appalachia, VA and Cairo, MO.

The estimated cost of gas to go from Appalachia to Cairo is $87.13.

During the route, an average car will release 523.34 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Appalachia, VA and Cairo, MO

If you want to meet halfway between Appalachia, VA and Cairo, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 38.191651 and -87.343342, or 38º 11' 29.9436" N, 87º 20' 36.0312" W. This location is 332.57 miles away from Appalachia, VA and Cairo, MO and it would take approximately 6 hours 27 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Lynnville, IN, situated 334 miles from Appalachia, VA and 332 miles from Cairo, MO. It would take 6 hours 39 mins to go from Appalachia to Lynnville and 6 hours 17 mins to go from Cairo to Lynnville.

Major City Closest to Halfway Point

The major city closest to the halfway point between Appalachia, VA and Cairo, MO is Evansville, IN, situated 370 miles from Appalachia, VA and 326 miles from Cairo, MO. It would take 7 hours 14 mins to go from Appalachia to Evansville and 6 hours 21 mins to go from Cairo to Evansville.