Distance between cities › USA › North Carolina › Boone, NC › Distance from Boone to Cairo Book Hotels

Distance from Boone, NC to Cairo, MO

Distance

782 mi

Time

15 hours 9 mins

Gas Cost

$73 - $142

There are 629.32 miles from Boone to Cairo in northwest direction and 782 miles (1,258.51 kilometers) by car, following the I-64 and SR 62 route.

Boone and Cairo are 15 hours 9 mins far apart, if you drive non-stop .

This is the fastest route from Boone, NC to Cairo, MO.

Please note the time difference between Boone, NC and Cairo, MO is 1 hour. The current time in Boone is 1:28 am and the current time in Cairo is 12:28 am.

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Lowest Price Rental Cars in Boone, NC

Planning on renting a car to go from Boone, NC to Cairo, MO? Here there are some offers to rent a car in Boone, NC

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Boone »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 31.40 gallons of gas to cover the route between Boone, NC and Cairo, MO.

The estimated cost of gas to go from Boone to Cairo is $102.44.

During the route, an average car will release 615.27 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Boone, NC and Cairo, MO

If you want to meet halfway between Boone, NC and Cairo, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 38.245038 and -86.448916, or 38º 14' 42.1368" N, 86º 26' 56.0976" W. This location is 390.98 miles away from Boone, NC and Cairo, MO and it would take approximately 7 hours 34 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Sulphur, IN, situated 405 miles from Boone, NC and 379 miles from Cairo, MO. It would take 8 hours 4 mins to go from Boone to Sulphur and 7 hours 9 mins to go from Cairo to Sulphur.