Distance between cities › USA › Illinois › Itasca, IL › Distance from Itasca to Cairo Book Hotels

Distance from Itasca, IL to Cairo, MO

Distance

377 mi

Time

7 hours 5 mins

Gas Cost

$35 - $68

There are 287.71 miles from Itasca to Cairo in southwest direction and 377 miles (606.72 kilometers) by car, following the I-55 route.

Itasca and Cairo are 7 hours 5 mins far apart, if you drive non-stop .

This is the fastest route from Itasca, IL to Cairo, MO.

Itasca, IL and Cairo, MO are in the same time zone (CDT). Current time in both locations is 5:48 am.

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Lowest Price Rental Cars in Itasca, IL

Planning on renting a car to go from Itasca, IL to Cairo, MO? Here there are some offers to rent a car in Itasca, IL

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Itasca »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 15.15 gallons of gas to cover the route between Itasca, IL and Cairo, MO.

The estimated cost of gas to go from Itasca to Cairo is $49.41.

During the route, an average car will release 296.75 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Itasca, IL and Cairo, MO

If you want to meet halfway between Itasca, IL and Cairo, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 39.742959 and -89.644429, or 39º 44' 34.6524" N, 89º 38' 39.9444" W. This location is 188.58 miles away from Itasca, IL and Cairo, MO and it would take approximately 3 hours 32 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Southern View, IL, situated 201 miles from Itasca, IL and 179 miles from Cairo, MO. It would take 3 hours 48 mins to go from Itasca to Southern View and 3 hours 23 mins to go from Cairo to Southern View.

Major City Closest to Halfway Point

The major city closest to the halfway point between Itasca, IL and Cairo, MO is Springfield, IL, situated 198 miles from Itasca, IL and 180 miles from Cairo, MO. It would take 3 hours 47 mins to go from Itasca to Springfield and 3 hours 26 mins to go from Cairo to Springfield.