Distance between cities › USA › Minnesota › Saint Cloud, MN › Distance from Saint Cloud to Cairo Book Hotels

Distance from Saint Cloud, MN to Cairo, MO

Distance

506 mi

Time

9 hours 37 mins

Gas Cost

$47 - $92

There are 426.81 miles from Saint Cloud to Cairo in southeast direction and 506 miles (814.33 kilometers) by car, following the I-35W route.

Saint Cloud and Cairo are 9 hours 37 mins far apart, if you drive non-stop .

This is the fastest route from Saint Cloud, MN to Cairo, MO. The halfway point is Ellsworth, IA.

Saint Cloud, MN and Cairo, MO are in the same time zone (CDT). Current time in both locations is 4:05 am.

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Lowest Price Rental Cars in Saint Cloud, MN

Planning on renting a car to go from Saint Cloud, MN to Cairo, MO? Here there are some offers to rent a car in Saint Cloud, MN

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Saint Cloud »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 20.33 gallons of gas to cover the route between Saint Cloud, MN and Cairo, MO.

The estimated cost of gas to go from Saint Cloud to Cairo is $66.31.

During the route, an average car will release 398.24 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Saint Cloud, MN and Cairo, MO

If you want to meet halfway between Saint Cloud, MN and Cairo, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 42.395844 and -93.569359, or 42º 23' 45.0384" N, 93º 34' 9.6924" W. This location is 253.07 miles away from Saint Cloud, MN and Cairo, MO and it would take approximately 4 hours 48 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Ellsworth, IA, situated 257 miles from Saint Cloud, MN and 250 miles from Cairo, MO. It would take 3 hours 51 mins to go from Saint Cloud to Ellsworth and 4 hours 21 mins to go from Cairo to Ellsworth.