Distance between cities › USA › South Dakota › Vermillion, SD › Distance from Vermillion to Cairo Book Hotels

Distance from Vermillion, SD to Cairo, MO

Distance

408 mi

Time

7 hours 36 mins

Gas Cost

$38 - $74

There are 324.73 miles from Vermillion to Cairo in southeast direction and 408 miles (656.61 kilometers) by car, following the I-29 route.

Vermillion and Cairo are 7 hours 36 mins far apart, if you drive non-stop .

This is the fastest route from Vermillion, SD to Cairo, MO. The halfway point is Craig, MO.

Vermillion, SD and Cairo, MO are in the same time zone (CDT). Current time in both locations is 3:22 pm.

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Lowest Price Rental Cars in Vermillion, SD

Planning on renting a car to go from Vermillion, SD to Cairo, MO? Here there are some offers to rent a car in Vermillion, SD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Vermillion »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 16.40 gallons of gas to cover the route between Vermillion, SD and Cairo, MO.

The estimated cost of gas to go from Vermillion to Cairo is $53.50.

During the route, an average car will release 321.30 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Vermillion, SD and Cairo, MO

If you want to meet halfway between Vermillion, SD and Cairo, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 40.204006 and -95.345238, or 40º 12' 14.4216" N, 95º 20' 42.8568" W. This location is 204.18 miles away from Vermillion, SD and Cairo, MO and it would take approximately 3 hours 48 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Craig, MO, situated 218 miles from Vermillion, SD and 191 miles from Cairo, MO. It would take 3 hours 14 mins to go from Vermillion to Craig and 3 hours 21 mins to go from Cairo to Craig.