Distance between cities › USA › South Dakota › Vermillion, SD › Distance from Vermillion to Madison Book Hotels

Distance from Vermillion, SD to Madison, MO

Distance

425 mi

Time

7 hours 59 mins

Gas Cost

$40 - $77

There are 335.30 miles from Vermillion to Madison in southeast direction and 425 miles (683.97 kilometers) by car, following the I-29 route.

Vermillion and Madison are 7 hours 59 mins far apart, if you drive non-stop .

This is the fastest route from Vermillion, SD to Madison, MO. The halfway point is Mound City, MO.

Vermillion, SD and Madison, MO are in the same time zone (CDT). Current time in both locations is 7:07 pm.

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Lowest Price Rental Cars in Vermillion, SD

Planning on renting a car to go from Vermillion, SD to Madison, MO? Here there are some offers to rent a car in Vermillion, SD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Vermillion »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 17.06 gallons of gas to cover the route between Vermillion, SD and Madison, MO.

The estimated cost of gas to go from Vermillion to Madison is $55.66.

During the route, an average car will release 334.30 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Vermillion, SD and Madison, MO

If you want to meet halfway between Vermillion, SD and Madison, MO or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 40.121929 and -95.231651, or 40º 7' 18.9444" N, 95º 13' 53.9436" W. This location is 212.43 miles away from Vermillion, SD and Madison, MO and it would take approximately 3 hours 59 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Mound City, MO, situated 227 miles from Vermillion, SD and 199 miles from Madison, MO. It would take 3 hours 21 mins to go from Vermillion to Mound City and 3 hours 36 mins to go from Madison to Mound City.